NCIt definition : A recombinant, fully human monoclonal antibody against the inhibitory T-cell receptor
T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis
A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory
and antineoplastic activities. Upon administration, the anti-TIM-3 monoclonal antibody
Sym023 binds to TIM-3 expressed on certain T-cells, including tumor infiltrating lymphocytes
(TILs). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes
and enhances cytotoxic T-cell-mediated tumor cell lysis, which results in a reduction
in tumor cell proliferation. TIM-3, a transmembrane protein and immune checkpoint
receptor, is associated with tumor-mediated immune suppression.;
Semantic type(s)