NCIt synonyms : Anti-Lymphocyte Activation Gene 3 Protein Monoclonal Antibody BI 754111; Anti-LAG3 Monoclonal Antibody BI 754111;
NCIt definition : A monoclonal antibody directed against the inhibitory receptor lymphocyte activation
gene 3 protein (LAG3; LAG-3), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon administration,miptenalimab binds to LAG3 expressed on tumor-infiltrating
lymphocytes (TILs) and blocks its binding with major histocompatibility complex (MHC)
class II molecules expressed on tumor cells. This activates antigen-specific T-lymphocytes
and enhances cytotoxic T-cell-mediated tumor cell lysis, which leads to a reduction
in tumor growth. LAG3, a member of the immunoglobulin superfamily (IgSF), is expressed
on various immune cells, and negatively regulates both proliferation and activation
of T-cells. Its expression on TILs is associated with tumor-mediated immune suppression.;
Semantic type(s)