Guselkumab - CISMeF

Preferred Label : Guselkumab;

NCIt definition : An orally available, human, immunoglobulin G1 (IgG1) kappa, monoclonal antibody directed against the p19 protein subunit of interleukin-23 (IL-23), with immunomodulating activity. Upon administration, guselkumab binds to the p19 subunit of IL-23, thereby blocking the binding of IL-23 to the IL-23 receptor. This inhibits IL-23-mediated signaling and the differentiation of CD4-positive T-cells into Th1 and Th17 cells. This prevents Th1- and Th17-mediated immune responses and inhibits the production of pro-inflammatory cytokines. This may prevent or reduce symptoms and severity of immune-mediated inflammatory disorders. IL-23 plays a key role in the regulation of inflammation and the immune system, and modulates the release of various pro-inflammatory cytokines and chemokines. It is upregulated in various immune-mediated inflammatory disorders.;

UNII : 089658A12D;

CAS number : 1350289-85-8;

Drug name : Tremfya;

Molecule name : CNTO 1959;

Details

Origin ID

C150390;

UMLS CUI

C3852217;

Currated CISMeF NLP mapping
- Guselkumab [ICD-11 Extension code]
- Guselkumab [SMS substance]
- Guselkumab [Anticorps monoclonal]
- Guselkumab (substance) [SNOMED CT concept]
- guselkumab [MeSH concept]
- guselkumab [MeSH Supplementary Concept]
- guselkumab [ATC Code]
See also inter- (CISMeF)
- Product containing guselkumab (medicinal product) [SNOMED CT concept]
- Tremfya [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Guselkumab (substance) [SNOMED CT concept]
- Product containing guselkumab (medicinal product) [SNOMED CT concept]
- guselkumab [ATC Code]
- guselkumab [MeSH concept]
- guselkumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Interleukin-23 Subunit Alpha [NCIt concept]

Keyword's position in hierarchy(ies) :

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