Preferred Label : EP4 Antagonist ONO-4578;
NCIt synonyms : Prostaglandin E2 Receptor Antagonist ONO-4578; PGE2 Receptor Antagonist ONO-4578; Selective PGE2 Receptor 4 Antagonist ONO-4578;
NCIt definition : An orally bioavailable antagonist of the prostaglandin E2 receptor subtype 4 (PTGER4;
EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon
administration, the EP4 antagonist ONO-4578 selectively targets and binds to EP4,
inhibiting the binding of the immunosuppressive prostaglandin E2 (PGE2) to EP4. This
prevents the activation of EP4 and inhibits PGE2-EP4-mediated signaling, thereby inhibiting
proliferation of tumor cells in which the PGE2-EP4 signaling pathway is over-activated.
In addition, EP4 inhibition prevents the activity of tumor-associated myeloid cells
(TAMCs) in the tumor microenvironment (TME) by inhibiting interleukin-23 (IL-23) production
and the IL-23-mediated expansion of Th17 cells. EP4, a prostanoid receptor, is a G
protein-coupled receptor that is expressed in certain types of cancers; it promotes
tumor cell proliferation and invasion.;
Molecule name : ONO-4578; BMS-986310; ONO 4578;
NCI Metathesaurus CUI : CL552175;
Origin ID : C150376;
UMLS CUI : C4725689;
Semantic type(s)
- concept_is_in_subset
- has_target
