Preferred Label : ERK1/2 Inhibitor ERAS-007;
NCIt synonyms : ERK Inhibitor ASN007; ERK1/2 Inhibitor ASN007; ERK Inhibitor ERAS-007;
NCIt definition : An orally bioavailable inhibitor of the extracellular signal-regulated kinases 1 (ERK1)
and 2 (ERK2), with potential antineoplastic activity. Upon oral administration, ERAS-007
specifically binds to and inhibits the serine/threonine-protein kinase activities
of both ERK1 and ERK2, thereby preventing the phosphorylation of ERK1/2 substrates
and the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal
transduction pathways. This results in the inhibition of ERK-dependent proliferation
and survival of tumor cells. The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK
pathway, is hyperactivated in a variety of tumor cell types due to mutations in upstream
targets. It plays a key role in the proliferation, differentiation and survival of
tumor cells.;
Molecule name : ASN 007; ERAS 007; ERAS-007; ASN-007;
NCI Metathesaurus CUI : CL552048;
Origin ID : C150248;
UMLS CUI : C5554545;
Semantic type(s)
- concept_is_in_subset
- has_target
