Phenyl Acetate

Preferred Label : Phenyl Acetate;

NCIt synonyms : Acetylphenol; Acetic Acid Phenyl Ester;

NCIt related terms : phenylacetate;

NCIt definition : An aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibition, and apoptosis in tumor cells. Implicated mechanisms of action include decreased protein prenylation, activation of the peroxisome proliferation-activated receptors, inhibition of DNA methylation, and depletion of glutamine. (NCI04);

Alternative definition : NCI-GLOSS: A drug being studied in the treatment of cancer.;

UNII : 355G9R500Y;

InChIKey : IPBVNPXQWQGGJP-UHFFFAOYSA-N;

CAS number : 122-79-2;

Chemical formula : C8H8O2;

NSC code : 27795;

ChEBI ID : CHEBI:8082;

Codes from synonyms : NSC0027795; CDR0000045383;

Details

Origin ID

C1501;

UMLS CUI

C0220893;

Currated CISMeF NLP mapping
- Phenylacetate [LOINC component]
- Phenylacetate (substance) [SNOMED CT concept]
- phenylacetate [MeSH concept]
- phenylacetates [MeSH Descriptor]
- phenylacetates [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Phenylacetate [LOINC component]
- Phenylacetate (substance) [SNOMED CT concept]
- phenylacetate [MeSH concept]
chemical_or_drug_affects_gene_product
- Peroxisome Proliferator-Activated Receptor Gamma [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Activation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Methylation Inhibition [NCIt concept]
- Gene Regulation Process [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Positive Regulation of Cell Differentiation [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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