Lodenosine - CISMeF

Preferred Label : Lodenosine;

NCIt synonyms : 2'-Beta-Fluoro-2',3'-Dideoxyadenosine; 2'-F-dd-ara-A; 2'-Fluoro-2',3'-Dideoxyadenosine; 9-(2,3-Dideoxy-2-fluoro-beta-D-threo-pentofuranosyl) Adenine; 2'-FddA; 2'-F-dd-araA; 2 Fluoro-2 3 Dideoxyadenosine; 9-(2,3-Dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)-9H-purin-6-amine; F-ddA;

NCIt definition : A nucleoside reverse transcriptase inhibitor analog of adenosine. Lodenosine is a synthetic purine fluoro-dideoxyadenosine derivative that was rationally designed to have improved chemical and enzymatic stability. It has shown activity against clinical isolates and cell lines that are resistant to AZT, dideoxyinosine, and dideoxycytosine.;

UNII : 3WB2LGT4R1;

InChIKey : KBEMFSMODRNJHE-JFWOZONXSA-N;

CAS number : 110143-05-0; 110143-10-7;

Molecule name : DRG-0246;

Chemical formula : C10H12FN5O2;

NSC code : 613792;

Details

Origin ID

C1499;

UMLS CUI

C0649962;

Automatic exact mappings (from CISMeF team)
- lodenosine [MeSH Supplementary Concept]
- lodenosine [MeSH concept]
Currated CISMeF NLP mapping
- 2-fluoro-2',3'-dideoxyadenosine [MeSH concept]
- 2-fluoro-2',3'-dideoxyadenosine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- lodenosine [MeSH concept]
- lodenosine [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Reverse Transcriptase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Reverse Transcription Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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