Preferred Label : PKC-beta Inhibitor MS-553;
NCIt synonyms : PKC-b Inhibitor MS-553;
NCIt definition : An orally available inhibitor of the beta-isoform of protein kinase C (PKC), with
potential immunosuppressive and antineoplastic activities. Upon oral administration,
PKC-beta inhibitor MS-553 selectively binds to and inhibits PKC-beta, which prevents
the activation of PKC-beta-mediated signaling pathways. This may lead to the induction
of cell cycle arrest and apoptosis in susceptible tumor cells. PKC-beta, a serine/threonine
protein kinase overexpressed in certain types of cancer cells, is involved in tumor
cell differentiation, proliferation, invasion and survival.;
Molecule name : MS-553; MS 553;
NCI Metathesaurus CUI : CL550994;
Origin ID : C148422;
UMLS CUI : C4725022;
Semantic type(s)
- concept_is_in_subset
- has_target
