Preferred Label : IDO1 Inhibitor MK-7162;
NCIt synonyms : Indoleamine-2,3-dioxygenase-1 Inhibitor MK-7162;
NCIt definition : An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential
immunomodulating and antineoplastic activities. Upon administration, IDO1 inhibitor
MK-7162 specifically targets and binds to IDO1, a cytosolic enzyme responsible for
the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine.
By inhibiting IDO1 and decreasing kynurenine in tumor cells, MK-7162 restores and
promotes the proliferation and activation of various immune cells, including dendritic
cells (DCs), natural killer (NK) cells and T-lymphocytes. This agent may also induce
increased interferon (IFN) production, which may lead to a reduction in tumor-associated
regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in
many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against and inhibit
the growth of the IDO1-expressing tumor cells. IDO1, an enzyme overexpressed by multiple
tumor cell types, plays an important role in immunosuppression. Tryptophan depletion
inhibits T-lymphocyte proliferation and activation, and suppresses the immune system.;
Molecule name : MK 7162; MK-7162;
NCI Metathesaurus CUI : CL550836;
Origin ID : C148235;
UMLS CUI : C4724920;
Semantic type(s)
- concept_is_in_subset
- has_target
