NCIt definition : An immunoglobulin G4 (IgG4) humanized monoclonal antibody directed against the negative
immunoregulatory human cell surface receptor programmed cell death 1 (PD-1; PD1; PDCD1;
CD279), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, geptanolimab binds to and inhibits PD-1 and its downstream signaling
pathways. This may restore immune function through the activation of T-cells and cell-mediated
immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin
superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively
regulates T-cell activation and effector function when activated by its ligands programmed
cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion
from host immunity.;
UNII : FME52R2SGN;
CAS number : 2348469-43-0;
Molecule name : CBT-501; GB-226; CBT 501; APL-501;
Semantic type(s)