" /> Denileukin Diftitox - CISMeF





Preferred Label : Denileukin Diftitox;

NCIt synonyms : DAB389IL-2; DAB389 Interleukin-2; DAB(389)IL-2; Interleukin-2 Fusion Toxin; DAB389 Interleukin-2 Immunotoxin; Interleukin-2 Fusion Protein; DAB(389)-Interleukin-2; DAB389IL2; Diphtheria Toxin Fragment-Interleukin-2 Fusion Protein E7777; DABIL2;

NCIt related terms : Ontak;

NCIt definition : A cytotoxic recombinant fusion protein consisting of the human cytokine interleukin-2 (IL-2) fused to diphtheria toxin fragments A and B, containing both the catalytic and translocation domains, with potential antineoplastic activity. Upon administration, the IL-2 moiety of denileukin difitox targets and binds to IL-2 receptors. After internalization by IL-2 receptor-expressing cells via endocytosis, denileukin difitox is proteolytically cleaved. This releases the catalytic domain of the toxin moiety, which catalyzes the transfer of the ADP-ribose moiety of NAD to a diphthamide residue of elongation factor 2 (EF-2). This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in an inhibition of translation and cell death.;

Alternative definition : NCI-GLOSS: A drug used to treat cutaneous T-cell lymphoma that can bind the cytokine IL-2 and that has not responded to other treatment. It is also being studied in the treatment of other types of cancer. Ontak is made by combining a part of IL-2 with a bacterial toxin. The IL-2 part of the drug attaches to the cancer cells and then the toxin kills the cells. Ontak is a type of immunotoxin and a type of fusion toxin.;

UNII : 25E79B5CTM;

CAS number : 173146-27-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 173146-27-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Ontak;

Molecule name : LY335348; E7777;

NSC code : 714744;

Codes from synonyms : CDR0000520890; CDR0000045454; 152;

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15/05/2024


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