Preferred Label : Apremilast;

NCIt synonyms : ( )-N-(2-((1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxo- 2,3-dihydro-1H-isoindol-4-yl)acetamide;

NCIt definition : An orally bioavailable, small molecule inhibitor of phosphodiesterase 4 (PDE4), with potential anti-inflammatory activity. Upon oral administration, apremilast targets, binds to and inhibits the activity of PDE4, thereby blocking cyclic adenosine monophosphate (cAMP) degradation and increasing intracellular cAMP levels. This may decrease the production of the proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha). PDE4 is an enzyme that plays an important role in the degradation of cAMP and in cytokine production in inflammatory cells.;

UNII : UP7QBP99PN;

InChIKey : IMOZEMNVLZVGJZ-QGZVFWFLSA-N;

CAS number : 608141-41-9;

Drug name : Otezla;

Molecule name : CC-10004; CC 10004;

NCI Metathesaurus CUI : CL545011;

Détails


Consulter ci-dessous une sélection des principales ressources :

Vous pouvez consulter :


https://www.rheuma-net.ch/fr/doc/apremilast-f/viewdocument/354
2024
Switzerland
guideline
Background Treatment
apremilast
apremilast
Apremilast, (+/-)-
Apremilast

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31/07/2025


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