Preferred Label : Anti-MUC16/MMAE Antibody-Drug Conjugate DMUC4064A;
NCIt synonyms : ADC DMUC4064A; THIOMAB-drug Conjugate DMUC4064A;
NCIt related terms : DMUC-4064A;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody against human mucin
16 (MUC16; cancer antigen 125; CA125; FLJ14303) conjugated to monomethyl auristatin
E (MMAE), an auristatin derivative and potent microtubule disrupting agent, with potential
antineoplastic activity. Upon administration, anti-MUC16/MMAE ADC DMUC4064A binds
to MUC16 located on the tumor cell surface. After internalization of the agent, the
MMAE moiety is released and binds to tubulin and inhibits its polymerization, which
results in G2/M phase arrest and apoptosis. MUC16, a member of the mucin family glycoproteins,
is overexpressed in a variety of tumor cells and plays a key role in tumor cell proliferation.;
UNII : D5STG0624V;
Molecule name : DMUC4064A; RG7882;
NCI Metathesaurus CUI : CL545030;
Origin ID : C147031;
UMLS CUI : C4688593;
Semantic type(s)
- concept_is_in_subset
- has_target
