NCIt definition : An orally available ataxia telangiectasia and Rad3-related (ATR)-specific kinase inhibitor,
with potential antineoplastic activity. Upon oral administration, elimusertib selectively
binds to and inhibits the activity of ATR, which prevents ATR-mediated signaling.
This inhibits DNA damage checkpoint activation, disrupts DNA damage repair and induces
apoptosis in ATR-overexpressing tumor cells. ATR, a serine/threonine protein kinase
upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell
cycle progression and cell survival.;
UNII : 7N13IK9LNH;
InChIKey : YBXRSCXGRPSTMW-CYBMUJFWSA-N;
CAS number : 1876467-74-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1876467-74-1
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G-SRS /a ;
Semantic type(s)