Nafoxidine Hydrochloride

Preferred Label : Nafoxidine Hydrochloride;

NCIt related terms : 1-[2-[4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine Hydrochloride;

NCIt definition : The hydrochloride salt of the partial estrogen antagonist nafoxidine. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04);

UNII : SU8WBD61G1;

InChIKey : HJOOGTROABIIIU-UHFFFAOYSA-N;

CAS number : 1847-63-8;

Molecule name : U-11,000A; U 11100A;

Chemical formula : C29H31NO2.HCl;

NSC code : 70735;

Codes from synonyms : 05813;

Details

Origin ID

C1448;

UMLS CUI

C0205850;

Automatic exact mappings (from CISMeF team)
- nafoxidine [MeSH Descriptor]
Currated CISMeF NLP mapping
- Nafoxidine Hydrochloride [MeSH concept]
- nafoxidine hydrochloride [SNOMED Notion]
False automatic mappings
- Nafoxidine hydrochloride (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nafoxidine Hydrochloride [MeSH concept]
- Nafoxidine hydrochloride (substance) [SNOMED CT concept]
- nafoxidine hydrochloride [SNOMED Notion]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Nafoxidine [NCIt concept]
is_salt_form_of
- Nafoxidine [NCIt concept]

Keyword's position in hierarchy(ies) :

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