Preferred Label : Tebotelimab;
NCIt synonyms : PD-1 x LAG-3 DART Protein MGD013; Dual-affinity Retargeting Protein MGD013; PD-1 x LAG-3 Bispecific DART Molecule MGD013; PD-1 x LAG-3 DART Molecule MGD013; Bispecific DART Protein MGD013; Anti-PD-1/Anti-LAG-3 DART Protein MGD013;
NCIt definition : An Fc-bearing, humanized antibody-like protein that specifically recognizes the immune
checkpoint molecules programmed cell death 1 (PD-1; PD1; PDCD1; CD279; Programmed
Death 1) and lymphocyte activation gene-3 (LAG-3; LAG3; CD223), with potential T-lymphocyte
immunomodulatory and antineoplastic activities. Upon administration, tebotelimab specifically
binds to both PD-1 and LAG-3, which are both expressed on T-cells. The dual blockade
of the PD-1 and LAG-3 pathways enables potent activation of a cytotoxic T-lymphocyte
(CTL)-mediated immune response against tumor cells. PD-1 and LAG-3 play key roles
in suppressing T-cell activation.;
UNII : L62556GPXB;
CAS number : 2245725-04-4;
Molecule name : MGD-013; MGD 013;
NCI Metathesaurus CUI : CL542159;
Origin ID : C143957;
UMLS CUI : C5446317;
Semantic type(s)
- concept_is_in_subset
- has_target
