Preferred Label : Trimeric GITRL-Fc OMP-336B11;
NCIt synonyms : GITRL-Fc Trimer; GITRL-Fc;
NCIt definition : A Fc-engineered human fusion protein composed of two trimers of tumor necrosis factor
(ligand) superfamily, member 18 (TNFSF18; GlTRL) linked to an immunoglobulin Fc domain
(GITRL-Fc), with potential immunostimulatory and antineoplastic activities. Upon administration,
trimeric GITRL-Fc OMP-336B11 targets, binds to and activates its co-stimulatory surface
receptor (glucocorticoid-induced tumor necrosis factor receptor (GITR; TNFRSF18) expressed
on T-lymphocytes and certain tumor cell types. This activates T-lymphocytes, causes
T-lymphocyte proliferation and suppresses the activity of regulatory T-cells (Treg).
This promotes cytotoxic T-lymphocyte (CTL)-mediated killing of tumor cells. GITRL,
a member of the tumor necrosis factor (TNF) family of ligands, functions to activate
the co-stimulatory receptor GITR to enhance T-cell modulated immune responses.;
Molecule name : OMP 336B11; OMP-336B11;
NCI Metathesaurus CUI : CL541604;
Origin ID : C143155;
UMLS CUI : C4684969;
Semantic type(s)
- concept_is_in_subset
- has_target
