" /> Encelimab - CISMeF





Preferred Label : Encelimab;

NCIt synonyms : Anti-LAG-3 Monoclonal Antibody TSR-033; Anti-Lymphocyte Activation Gene 3 Protein Monoclonal Antibody TSR-033; Anti-LAG3 Monoclonal Antibody TSR-033;

NCIt definition : A humanized, immunoglobulin G4 (IgG4) monoclonal antibody directed against the inhibitory receptor lymphocyte activation gene 3 protein (LAG3; LAG-3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,encelimab binds to LAG3 expressed on tumor-infiltrating lymphocytes (TILs) and blocks its binding with major histocompatibility complex (MHC) class II molecules expressed on tumor cells. This activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which leads to a reduction in tumor growth. LAG3, a member of the immunoglobulin superfamily (IgSF), is expressed on various immune cells, and negatively regulates both proliferation and activation of T-cells. Its expression on TILs is associated with tumor-mediated immune suppression.;

UNII : N151VZIIPD;

CAS number : 2173096-82-5;

Molecule name : TSR 033; TSR-033;

NCI Metathesaurus CUI : CL541410;

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07/05/2025


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