NCIt definition : A humanized monoclonal antibody directed against the negative immunoregulatory human
cell surface receptor programmed cell death 1 (PD-1 , PCD-1; PDCD1), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1
monoclonal antibody Sym021 binds to and inhibits PD-1 activation and its downstream
signaling pathways. This may restore immune function through the activation of T-cells
and cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein
in the immunoglobulin superfamily (IgSF), is expressed on T-cells and functions as
an immune checkpoint that negatively regulates T-cell activation and effector function
when activated by its ligands programmed cell death ligand 1 (PD-L1) or 2 (PD-L2).
Activated PD-1 plays an important role in tumor evasion from host immunity.;
UNII : K45ZNW8WU9;
CAS number : 2233593-42-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2233593-42-3
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G-SRS /a ;
Semantic type(s)