NCIt definition : A humanized monoclonal antibody directed against the negative immunoregulatory human
cell surface receptor programmed cell death 1 (PD-1 , PCD-1; PDCD1), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1
monoclonal antibody Sym021 binds to and inhibits PD-1 activation and its downstream
signaling pathways. This may restore immune function through the activation of T-cells
and cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein
in the immunoglobulin superfamily (IgSF), is expressed on T-cells and functions as
an immune checkpoint that negatively regulates T-cell activation and effector function
when activated by its ligands programmed cell death ligand 1 (PD-L1) or 2 (PD-L2).
Activated PD-1 plays an important role in tumor evasion from host immunity.;
Semantic type(s)