Preferred Label : Etigilimab;
NCIt synonyms : Anti-TIGIT OMP-313M32; WHO 10742; Immunoglobulin G1, Anti-(Human Receptor TIGIT(T-cell Immunoreceptor with Ig and iTIM
Domains)) (Humanized Mouse Monoclonal OMP-313M32 Gamma1-chain), Disulfide with Humanized
Mouse Monoclonal OMP-313M32 Kappa-chain, Dimer;
NCIt definition : A monoclonal antibody targeting the human co-inhibitory molecule and immune checkpoint
inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based
inhibitory motif (ITIM) domains (TIGIT), with potential immune checkpoint inhibitory
activity. Upon administration, etigilimab binds to TIGIT expressed on various immune
cells, including T-cells, and prevents the interaction of TIGIT with its ligands CD112
(nectin-2; poliovirus receptor related-2; PVRL2) and CD155 (poliovirus receptor; PVR;
nectin-like protein 5; NECL-5). This enhances the interaction of CD112 and CD155 with
the costimulatory receptor CD226 (DNAX Accessory molecule-1; DNAM-1), which is expressed
on immune cells, such as natural killer (NK) cells and CD8-positive T-cells, and leads
to CD226 dimerization and CD226-mediated signaling. This activates the immune system
to exert a T-cell-mediated immune response against cancer cells. TIGIT, a member of
the Ig super family and an immune inhibitory receptor, plays a key role in the suppression
of T-cell proliferation and activation; it is involved in tumor cell immune evasion
and the inhibition of antiviral immune responses.;
UNII : FC1ZF28VIT;
CAS number : 2044984-83-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2044984-83-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : OMP-313M32; OMP 313M32;
NCI Metathesaurus CUI : CL540712;
Origin ID : C142821;
UMLS CUI : C5235400;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
