Preferred Label : CD44 Targeted Agent SPL-108;
NCIt definition : A proprietary agent that targets the cancer stem cell (CSC) antigen CD44, with potential
antineoplastic activity. Although the mechanism of action has not been elucidated,
following subcutaneous administration, CD44 targeted agent SPL-108 binds to CD44 and
prevents the activation of various CD44-mediated signal transduction pathways, which
may lead to reduced proliferation of CD44-expressing tumor stem cells. CD44, a transmembrane
glycoprotein and hyaluronic acid receptor, is expressed in healthy tissue and overexpressed
in numerous cancer cell types; it plays a key role in the proliferation, migration
and survival of tumor cells.;
Molecule name : SPL-108; SPL 108;
NCI Metathesaurus CUI : CL540705;
Origin ID : C142813;
UMLS CUI : C4684835;
Semantic type(s)
- concept_is_in_subset
- has_target
