Thoracic NUT Carcinoma

Preferred Label : Thoracic NUT Carcinoma;

NCIt synonyms : Thoracic NMC;

NCIt definition : A highly aggressive, poorly differentiated carcinoma that arises from the thoracic structures. It is characterized by mutations and rearrangement of the NUT gene. It usually presents at an advanced stage with pleuritic chest pain and pleural effusion, non-productive cough, shortness of breath, and weigh loss.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL540737;

Details

Origin ID

C142781;

UMLS CUI

C4684820;

Disease excludes abnormal cell
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Excludes anatomical site(s)
- Neck [NCIt concept]
Has associated anatomic sites
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
Has cytogenetic abnormalities
- t(15;19)(q13;p13.1) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
disease_has_finding
- Aggressive Clinical Course [NCIt concept]
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Poorly Differentiated Lesion [NCIt concept]
disease_has_molecular_abnormality
- BRD4-NUT Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Midline Anatomic Structure [NCIt concept]
- Thoracic Cavity [NCIt concept]
disease_mapped_to_gene
- BRD4/NUTM1 Fusion Gene [NCIt concept]

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