NCIt definition : A humanized, immunoglobulin G4 (IgG4) monoclonal antibody (MAb) directed against the
inhibitory receptor lymphocyte activation gene-3 protein (LAG3), with potential immune
checkpoint inhibitory and antineoplastic activities. Upon administration, favezelimab
binds to LAG3 expressed on tumor-infiltrating lymphocytes (TILs) and blocks its binding
with major histocompatibility complex (MHC) class II molecules expressed on tumor
cells. This activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated
tumor cell lysis, which leads to a reduction in tumor growth. LAG3, a member of the
immunoglobulin superfamily (IgSF), is expressed on various immune cells, and negatively
regulates both proliferation and activation of T-cells. Its expression on TILs is
associated with tumor-mediated immune suppression.;
Semantic type(s)