Gallium Ga 68 Boclatixafortide

Preferred Label : Gallium Ga 68 Boclatixafortide;

NCIt synonyms : [68Ga] Pentixafor; Ga68 Pentixafor; 68Ga Pentixafor; Ga-68 Pentixafor; Pentixafor Gallium GA-68; Gallium Ga 68 Pentixafor; CPCR4-2 GA-68; 68GA-CPCR4-2;

NCIt related terms : GALLIUM (68GA) BOCLATIXAFORTIDE;

NCIt definition : A radioconjugate composed of a synthetic, cyclic pentapeptide analog of stromal-cell derived factor-1 (SDF-1 or CXCL12), which is a ligand for chemokine receptor C-X-C chemokine receptor type 4 (CXCR4), that is radiolabeled, via the macrocyclic chelating agent dodecanetetraacetic acid (DOTA), with the radioisotope gallium Ga 68 (Ga68; 68Ga), with potential use for imaging CXCR4-expressing cells upon positron emission tomography (PET)/computed tomography (CT). Upon administration of 68Ga pentixafor, the pentixafor moiety targets and binds to CXCR4-expressing cancer cells. Upon PET/CT, CXCR4-expressing cancer cells can be visualized and the expression status of the receptor can be assessed. CXCR4, a marker of poorly differentiated cells, is overexpressed on various cancer cells, and plays a key role in tumor growth, progression, invasiveness and metastasis.;

UNII : Y92N1ZLI87;

CAS number : 1345698-96-5;

Details

Origin ID

C141632;

UMLS CUI

C4042170;

Currated CISMeF NLP mapping
- 68Ga-pentixafor [MeSH Supplementary Concept]
- 68Ga-pentixafor [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
UMLS correspondences (same concept)
- 68Ga-pentixafor [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- C-X-C Chemokine Receptor Type 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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