Preferred Label : Iberdomide Hydrochloride;
NCIt synonyms : CC-220 Hydrochloride; 2,6-Piperidinedione, 3-(1,3-dihydro-4-((4-(4-morpholinylmethyl)phenyl)methoxy)-1-oxo-2H-isoindol-2-yl)-,
Hydrochloride (1:1), (3S)-;
NCIt definition : The hydrochloride salt form of iberdomide, a modulator of the E3 ubiquitin ligase
complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating
and pro-apoptotic activities. Upon administration, iberdomide specifically binds to
the cereblon (CRBN) part of the ligase complex, thereby affecting the ubiquitin E3
ligase activity, and targeting certain substrate proteins for ubiquitination. This
induces the proteasome-mediated degradation of certain transcription factors, including
Ikaros (IKZF1) and Aiolos (IKZF3) which are transcriptional repressors in T-cells.
This leads to a reduction of their protein levels, and the modulation of the immune
system, including activation of T-lymphocytes. In addition, this leads to a downregulation
of other proteins, including interferon regulatory factor 4 (IRF4), which plays a
key role in the proliferation of certain cancer cell types. CRBN, the substrate recognition
component of the E3 ubiquitin ligase complex, plays a key role in the ubiquitination
of certain proteins.;
UNII : 79L3645KFI;
InChIKey : VVHQVXXPZDALDV-BOXHHOBZSA-N;
CAS number : 1560678-63-8;
NCI Metathesaurus CUI : CL539551;
Origin ID : C141516;
UMLS CUI : C4683873;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
