Preferred Label : Milademetan;
NCIt synonyms : 2,6-Anhydro-5-((((3'R,4'S,5'R)-6'-chloro-4'-(2-chloro-3-fluoro-4-pyridinyl)-1',2'-dihydro-4,4-dimethyl-2''-oxodispiro(cyclohexane-1,2'-pyrrolidine-3',3''-(3H)indol)-5'-yl)carbonyl)amino)-3,4,5-trideoxy-L-erythro-hexonamide;
NCIt definition : An orally available MDM2 (murine double minute 2) antagonist with potential antineoplastic
activity. Upon oral administration, milademetan binds to, and prevents the binding
of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein
p53. By preventing this MDM2-p53 interaction, the proteasome-mediated enzymatic degradation
of p53 is inhibited and the transcriptional activity of p53 is restored. This results
in the restoration of p53 signaling and leads to the p53-mediated induction of tumor
cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway,
is overexpressed in cancer cells; it has been implicated in cancer cell proliferation
and survival.;
UNII : R3I80TLN7S;
InChIKey : RYAYYVTWKAOAJF-QISPRATLSA-N;
CAS number : 1398568-47-2;
Molecule name : DS-3032; RAIN-32;
NCI Metathesaurus CUI : CL539512;
Origin ID : C141432;
UMLS CUI : C4683813;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
