" /> Evobrutinib - CISMeF





Preferred Label : Evobrutinib;

NCIt synonyms : 1-(4-((6-Amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino)-methyl)-piperidin-1-yl)-propenone;

NCIt definition : An inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, evobrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.;

UNII : ZA45457L1K;

InChIKey : QUIWHXQETADMGN-UHFFFAOYSA-N;

CAS number : 1415823-73-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1415823-73-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

NCI Metathesaurus CUI : CL539517;

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15/05/2024


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