Preferred Label : Tirabrutinib Hydrochloride;
NCIt synonyms : ONO-4059 Hydrochloride; GS-4059 Hydrochloride;
NCIt definition : The hydrochloride salt form of tirabrutinib, an orally available formulation containing
an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic
activity. Upon administration, tirabrutinib covalently binds to BTK within B cells,
thereby preventing B cell receptor signaling and impeding B cell development. As a
result, this agent may inhibit the proliferation of B cell malignancies. BTK, a cytoplasmic
tyrosine kinase and member of the Tec family of kinases, plays an important role in
B lymphocyte development, activation, signaling, proliferation and survival.;
UNII : U374135N48;
InChIKey : UQYDCIJFACDXSG-GMUIIQOCSA-N;
CAS number : 1439901-97-9;
Drug name : Velexbru;
NCI Metathesaurus CUI : CL539518;
Origin ID : C141426;
UMLS CUI : C4683808;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
