Preferred Label : FPV Vaccine CV301;
NCIt synonyms : Boost Vaccine FPV-CV301; FPV-CV-301; FPV-CV301; Fowlpox-based FPV-CV301;
NCIt definition : A cancer vaccine consisting of a recombinant fowlpox viral (FPV) vector encoding both
the two human tumor-associated antigens (TAAs) carcinoembryonic antigen (CEA) and
mucin-1 (MUC-1), and TRICOM, which is comprised of the three human immune-enhancing
co-stimulatory molecules B7-1, ICAM-1 and LFA-3, with potential immunostimulatory
and antineoplastic activities. Upon subcutaneous administration following the administration
of a proprietary modified vaccinia Ankara developed by Bavarian Nordic-based prime
vaccine MVA-BN-CV301, the FPV vaccine CV301, which is used as a booster vaccine, activates
a cytotoxic T-lymphocyte (CTL) response against CEA- and MUC-1-expressing tumor cells.
In addition, the CV301-dependent anti-tumor CTL response upregulates the expression
of programmed cell death ligand 1 (PD-L1); therefore, when FPV-CV301 is combined with
a programmed cell death 1 (PD-1) immune checkpoint inhibitor, the antitumor effect
may be increased. The TAAs CEA and MUC-1 are overexpressed in a variety of cancers.;
NCI Metathesaurus CUI : CL539397;
Origin ID : C141298;
UMLS CUI : C4683695;
Semantic type(s)
- concept_is_in_subset
- has_target
