Preferred Label : Linrodostat;
NCIt synonyms : IDO-1 Inhibitor BMS-986205; (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propenamide; Indoleamine-pyrrole 2,3-Dioxygenase Inhibitor BMS-986205;
NCIt definition : An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential
immunomodulating and antineoplastic activities. Upon administration, linrodostat specifically
targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the
amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting
IDO1 and decreasing kynurenine in tumor cells, BMS-986205 restores and promotes the
proliferation and activation of various immune cells, including dendritic cells (DCs),
natural killer (NK) cells, and T-lymphocytes, and causes a reduction in tumor-associated
regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in
many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing
tumor cells, thereby inhibiting the growth of IDO1-expressing tumor cells. IDO1, overexpressed
by multiple tumor cell types, plays an important role in immunosuppression. Tryptophan
depletion inhibits T-lymphocyte proliferation and activation, and subsequently suppresses
the immune system.;
UNII : 0A7729F42K;
InChIKey : KRTIYQIPSAGSBP-ZACQAIPSSA-N;
CAS number : 1923833-60-6;
Molecule name : ONO-7701; BMS-986205; BMS 986205;
NCI Metathesaurus CUI : CL539187;
Origin ID : C141135;
UMLS CUI : C5139794;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
