Preferred Label : ERK1/2 Inhibitor KO-947;
NCIt synonyms : Extracellular Signal-regulated Kinase 1/2 Inhibitor KO-947; ERK Inhibitor KO-947;
NCIt definition : An inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential
antineoplastic activity. Upon intravenous administration, KO-947 specifically binds
to and inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated
protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the
inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway
is often upregulated in a variety of tumor cell types and plays a key role in the
proliferation, differentiation and survival of tumor cells.;
Molecule name : KO 947; KO-947;
NCI Metathesaurus CUI : CL539120;
Origin ID : C141074;
UMLS CUI : C4683496;
Semantic type(s)
- concept_is_in_subset
- has_target
