Preferred Label : ARID Domain;
NCIt synonyms : AT-Rich Interaction Domain; AT-Rich Interactive Domain; BRIGHT Domain;
NCIt definition : The approximately 100-amino acid ARID (AT-Rich Interaction Domain) DNA-binding domain
occurs in some transcriptional regulators (and perhaps modifiers of chromatin structure)
involved in embryonic development, cell lineage, and cell cycle control. The domain
shows more diversity in structure and function than the highly conserved sequence
suggests: at least six alpha helices separated by beta-strands, loops, or turns. Although
Bright, dead ringer, and MRF-2 preferentially bind to AT-rich sites, DNA binding of
ARID-proteins is not necessarily sequence specific; ARID protein p270 of the SWI-SNF
complex exhibits non-specific DNA binding activity. ARID family proteins may be involved
in a wide range of DNA interactions. Inappropriate expression of ARID proteins is
increasingly implicated in tumorigenesis.;
Origin ID : C14094;
UMLS CUI : C1515859;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
