Preferred Label : YXXP Motif;
NCIt synonyms : YXXP Domain;
NCIt definition : YXXP (tyrosine-X-X-Proline), a substrate sequence preferred by Abl tyrosine kinases,
is part of the SH2 domain that mediates certain interactions of SH2 containing proteins.
Although both phosphorylated- and unphosphorylated-YXXP can interacts with SH2 containing
proteins, the SH2 domain obtain sufficient binding specificity from the recognition
of adjacent residues to allow discrimination between different phosphorylated sites.
(NCI);
Origin ID : C14059;
UMLS CUI : C1520207;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
