ITAM - CISMeF

Preferred Label : ITAM;

NCIt synonyms : ARAM; Ag Recognition Activation Motif; Immunoreceptor Tyrosine-Based Activation Motif; Immunoreceptor Tyr-Based Activation Motif; Antigen Recognition Activation Motif; TAM; Tyrosine-Based Activation Motif;

NCIt definition : ITAM (Immunoreceptor Tyrosine-based Activation Motif) or ARAM (Ag Recognition Activation Motif) (Y-X-X-L-(X)6-8-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain, e.g. in CD247/x chain, FceRI g chain, or DAP12. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signaling machinery.;

Details

Origin ID

C14048;

UMLS CUI

C1521889;

Automatic exact mappings (from CISMeF team)
- 6-methoxypurine arabinoside [MeSH Supplementary Concept]
- Myeloproliferative syndrome, transient [OMIM Phenotype]
- immunoreceptor Tyrosine-Based activation motif [MeSH concept]
- immunoreceptor Tyrosine-Based activation motif [MeSH Descriptor]
- transient myeloproliferative syndrome [DO Concept]
False automatic mappings
- Eisenia bicyclis [MeSH concept]
- Eisenia brown algae [MeSH Supplementary Concept]
- Myopathy, tubular aggregate, 1 [OMIM Phenotype]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- immunoreceptor Tyrosine-Based activation motif [MeSH concept]
- immunoreceptor Tyrosine-Based activation motif [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
is_structural_domain_or_motif_of_gene_product
- B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain [NCIt concept]
- B-Cell Antigen Receptor Complex-Associated Protein Beta Chain [NCIt concept]

Keyword's position in hierarchy(ies) :

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