" /> immunoreceptor Tyrosine-Based activation motif - CISMeF





Preferred Label : immunoreceptor Tyrosine-Based activation motif;

MeSH definition : A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.;

MeSH synonym : immunoreceptor tyrosine based activation motif; Immuno-Receptor Tyrosine-Based activation motif; immuno receptor tyrosine based activation motif; immune receptor Tyrosine-Based activation motif; immune receptor tyrosine based activation motif;

Wikipedia link : https://en.wikipedia.org/wiki/Immunoreceptor tyrosine-based activation motif;

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A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.

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10/05/2025


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