Prednisolone Sodium Succinate

Preferred Label : Prednisolone Sodium Succinate;

NCIt definition : The sodium succinate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI);

UNII : 8223RR9DWF;

InChIKey : FKKAEMQFOIDZNY-CODXZCKSSA-M;

CAS number : 1715-33-9;

Drug name : Precortalon Aquosum;

Chemical formula : C25H31O8.Na;

NSC code : 9151;

Codes from synonyms : NSC0009151;

Details

Origin ID

C1403;

UMLS CUI

C0138274;

Automatic exact mappings (from CISMeF team)
- prednisolone hemisuccinate [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- prednisolone sodium succinate [MeSH concept]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Prednisolone [NCIt concept]
is_salt_form_of
- Prednisolone [NCIt concept]

Keyword's position in hierarchy(ies) :

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