Peplomycin Sulfate

Preferred Label : Peplomycin Sulfate;

NCIt synonyms : N1-(3-(((S)-(alpha-methylbenzyl))amino)propyl)bleomycinamide Sulfate (1:1) (Salt);

NCIt definition : The sulfate salt of the bleomycin analogue peplomycin. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04);

UNII : 6A668951HW;

InChIKey : ZHHIHQFAUZZMTG-BSVJBJGJSA-N;

CAS number : 73228-94-1;

Drug name : Pepleo;

Molecule name : NK-631;

Chemical formula : C61H88N18O21S2.H2O4S;

Details

Origin ID

C1400;

UMLS CUI

C0135982;

Automatic exact mappings (from CISMeF team)
- peplomycin [MeSH Descriptor]
Currated CISMeF NLP mapping
- peplomycin sulfate [MeSH concept]
False automatic mappings
- bleomycinamide, n1-[3-[(1-phenylethyl)amino]propyl]-, (s)-, sulfate (1:1) (salt) [Substance BNPC]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Antibiotic [UMLS semantic type]
UMLS correspondences (same concept)
- peplomycin sulfate [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Peplomycin [NCIt concept]
is_salt_form_of
- Peplomycin [NCIt concept]

Keyword's position in hierarchy(ies) :

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