Peplomycin - CISMeF

Preferred Label : Peplomycin;

NCIt synonyms : n1-[3[[(S)-alpha-methylbenzyl]amino]propyl]bleomycinamide; (S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamide; PEP;

NCIt related terms : PEPLEOMYCIN;

NCIt definition : A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04);

UNII : 56H9L80NIZ;

InChIKey : QIMGFXOHTOXMQP-GFAGFCTOSA-N;

CAS number : 68247-85-8;

Chemical formula : C61H88N18O21S2;

NSC code : 276382;

Codes from synonyms : NSC0276382;

Details

Origin ID

C1399;

UMLS CUI

C0135981;

Currated CISMeF NLP mapping
- Peplomycin [ICD-11 Extension code]
- peplomycin [Substance BNPC]
- peplomycin [MeSH Descriptor]
- peplomycin [MeSH concept]
False automatic mappings
- Epilepsy, partial, with pericentral spikes [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Antibiotic [UMLS semantic type]
UMLS correspondences (same concept)
- Peplomycin [ICD-11 Extension code]
- peplomycin [Substance BNPC]
- peplomycin [MeSH concept]
- peplomycin [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Peplomycin Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Peplomycin Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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