Atrial Natriuretic Factor

Preferred Label : Atrial Natriuretic Factor;

NCIt synonyms : Cardionatrin; NPPA; Atrionatriuretic Factor; ANF; ANP; Atriopeptin; Atrial Natriuretic Peptide;

NCIt definition : Atrial natriuretic factor (28 aa, 3 kDa) is encoded by the human NPPA gene. This protein is involved in both cardiac homeostasis and pregnancy.;

NCIt note : Atrial natriuretic factor can be cleaved by macrophage metalloelastase (MME), which promotes degradation of the hormone. (UniProt);

NCI Metathesaurus CUI : CL537991;

Details

Origin ID

C139911;

UMLS CUI

C4553325;

Automatic exact mappings (from CISMeF team)
- ANP [MedDRA LLT]
- Antinuclear antibody (substance) [SNOMED CT concept]
- HESX homeobox 1 [ORDO Gene]
- N-propionylprocainamide [MeSH Supplementary Concept]
- Natriuretic peptide precursor a [OMIM gene]
- natriuretic peptide A [ORDO Gene]
Currated CISMeF NLP mapping
- Atrial natriuretic factor [LOINC component]
- Atrial natriuretic factor (substance) [SNOMED CT concept]
- Atrial natriuretic peptide [MedDRA Preferred Term]
- atrial natriuretic factor [MeSH concept]
- atrial natriuretic factor [SNOMED Notion]
- atrial natriuretic factor [MeSH Descriptor]
OMIM relation
- Natriuretic peptide precursor a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- NPPA Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_is_element_in_pathway
- ALK Pathway [NCIt concept]
- Corticosteroid Cardioprotection Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cardiac Muscle Contraction [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Pregnancy [NCIt concept]
- Vasodilation [NCIt concept]

Keyword's position in hierarchy(ies) :

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