Natriuretic Peptides A

Preferred Label : Natriuretic Peptides A;

NCIt synonyms : CDP; NPPA; Cardiodilatin-Related Peptide; Atrial Natriuretic Polypeptides; Prepronatriodilatin; CDD; Natriuretic Peptide Precursor A; Cardiodilatin;

NCIt definition : Natriuretic peptides A (153 aa, 17 kDa) is encoded by the human NPPA gene. This protein is involved in uterine artery remodeling, trophoblast invasion, natriuresis, diuresis, and vasodilation.;

NCIt note : Natriuretic peptides A is cleaved on the C-terminal side of amino acid 123 by atrial natriuretic peptide-converting enzyme (Corin), which releases the 28 amino acid active hormone atrial natriuretic factor (ANF; atrionatriuretic factor, atriopeptin, atrial natriuretic peptide; ANP; cardionatrin). ANF can be cleaved by macrophage metalloelastase (MME), which promotes degradation of the hormone. (UniProt);

Details

Origin ID

C139910;

UMLS CUI

C1258629;

Automatic exact mappings (from CISMeF team)
- Aplasia of diaphragm (disorder) [SNOMED CT concept]
- Atrial natriuretic factor [LOINC component]
- CDKL5-deficiency disorder [ORDO Disease]
- Craniodiaphyseal dysplasia [OMIM Phenotype]
- Craniodiaphyseal dysplasia, autosomal dominant [OMIM Phenotype]
- Cut-like homeobox 1 [OMIM gene]
- Cytidine diphosphate (substance) [SNOMED CT concept]
- N-propionylprocainamide [MeSH Supplementary Concept]
- Natriuretic peptide [LOINC component]
- Natriuretic peptide precursor a [OMIM gene]
- Structural developmental anomalies of diaphragm [ICD-11 Category]
- cardiodilatin [MeSH concept]
- cut like homeobox 1 [ORDO Gene]
- cytidine diphosphate [MeSH Descriptor]
- natriuretic peptide A [ORDO Gene]
- natriuretic peptide A [HGNC gene]
- natriuretic peptides [MeSH concept]
False automatic mappings
- Chondrodysplasia punctata [ORDO Disease]
OMIM relation
- Natriuretic peptide precursor a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
UMLS correspondences (same concept)
- NPPA protein, human [MeSH Supplementary Concept]
- NPPA protein, human [MeSH concept]
Validated automatic mappings to NTBT
- natriuretic peptides [MeSH Descriptor]
gene_encodes_gene_product
- NPPA Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Cardiac Muscle Contraction [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Pregnancy [NCIt concept]
- Vasodilation [NCIt concept]

Keyword's position in hierarchy(ies) :

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