Preferred Label : Batoprotafib;
NCIt synonyms : PTPN11 Inhibitor TNO155; SHP2 Inhibitor TNO155;
NCIt definition : An inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src
homology region 2 domain phosphatase; PTPN11), with potential antineoplastic activity.
Upon oral administration,batoprotafib binds to and inhibits SHP2. This prevents SHP2-mediated
signaling, inhibits MAPK signaling and prevents growth of SHP2-expressing tumor cells.
SHP2, an oncoprotein overexpressed in a variety of cancer cell types, regulates cell
survival, differentiation and proliferation through activation of the RAS-RAF-ERK
signaling pathway. SHP2 also regulates programmed cell death 1 (PD-1)-mediated signal
transduction and is involved in immune checkpoint modulation.;
UNII : FPJWORQEGI;
CAS number : 1801765-04-7;
Molecule name : TNO155;
NCI Metathesaurus CUI : CL526915;
Origin ID : C139559;
UMLS CUI : C5706631;
Semantic type(s)
- concept_is_in_subset
- has_target
