" /> Vinorelbine Tartrate - CISMeF





Preferred Label : Vinorelbine Tartrate;

NCIt synonyms : Vinorelbine Ditartrate; Navelbine Ditartrate; NVB;

NCIt related terms : Navelbine;

NCIt definition : The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic properties. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to treat advanced non-small cell lung cancer. It blocks cell growth by stopping cell division and may cause cancer cells to die. It is a type of vinca alkaloid and a type of antimitotic agent.;

UNII : 253GQW851Q;

InChIKey : CILBMBUYJCWATM-PYGJLNRPSA-N;

CAS number : 125317-39-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 125317-39-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Eunades; Biovelbin; Navelbine;

Molecule name : KW-2307;

Chemical formula : C45H54N4O8.2C4H6O6;

NSC code : 608210;

ChEBI ID : CHEBI:32296;

Codes from synonyms : CDR0000658039; CDR0000658040; NSC0608210;

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15/05/2024


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