NCIt related terms : Navelbine; Navelbine ditartrate;
NCIt definition : The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the
periwinkle plant (Vinca rosea) with antineoplastic properties. Vinorelbine binds to
tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation
and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules
correlates with antitumor activity, whereas inhibition of axonal microtubules seems
to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids,
vinorelbine is more selective against mitotic than axonal microtubules in vitro, which
may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing
agent. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to treat advanced non-small cell lung cancer. It blocks cell
growth by stopping cell division and may cause cancer cells to die. It is a type of
vinca alkaloid and a type of antimitotic agent.;
UNII : 253GQW851Q;
InChIKey : CILBMBUYJCWATM-PYGJLNRPSA-N;
CAS number : 125317-39-7;
Drug name : Eunades; Biovelbin; Navelbine;
Molecule name : KW-2307; KW 2307;
Chemical formula : C45H54N4O8.2C4H6O6;
NSC code : 608210;
ChEBI ID : CHEBI:32296;
Codes from synonyms : CDR0000658039; CDR0000658040; NSC0608210;