NCIt definition : A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation
of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.
This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism;
calmodulin-dependent Ca -transport ATPase activity; cellular respiration; and nucleic
acid and lipid biosynthesis.;
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of plant drugs called vinca
alkaloids.;