Preferred Label : WAP Domain;
NCIt synonyms : WAP Motif; Whey Acidic Protein Domain;
NCIt definition : The WAP (Whey Acidic Protein) Domain contains eight characteristically-spaced cysteine
residues involved in disulphide bond formation and occurs in so-called 'four-disulphide
core' proteins. The spatial pattern of these conserved domain cysteines suggests that
the otherwise variable domain sequences may adopt a similar fold. The overall degree
of domain sequence similarity is low; a few Pro and Gly residues are reasonably well
conserved, as are polar/acidic residues between Cys3 and Cys4. WAP sequences are found
in Whey Acidic Protein; Elafin (a human skin elastase-specific inhibitor); rat WDNM1
Protein (involved in metastatic potential); Kallmann Syndrome Protein; and guinea
pig Caltrin-Like Protein II (inhibits calcium transport into spermatozoa). (NCI);
Origin ID : C13922;
UMLS CUI : C1520108;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
