NCIt definition : The dihydrochloride salt form of copanlisib, a phosphoinositide 3-kinase (PI3K) inhibitor
with potential antineoplastic activity. Copanlisib inhibits the activation of the
PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival
in susceptible tumor cell populations. Activation of the PI3K signaling pathway is
frequently associated with tumorigenesis and dysregulated PI3K signaling may contribute
to tumor resistance to a variety of antineoplastic agents.;