Preferred Label : BTK Inhibitor CT-1530;
NCIt definition : An inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia tyrosine
kinase), with potential antineoplastic activity. Upon administration, CT-1530 binds
to and inhibits the activity of BTK. This prevents both the activation of the B-cell
antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream
survival pathways. This leads to an inhibition of the growth of malignant B-cells
that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic
tyrosine kinases, is overexpressed or mutated in B-cell malignancies; it plays an
important role in the development, activation, signaling, proliferation and survival
of B-lymphocytes.;
Molecule name : CT 1530; CT-1530;
NCI Metathesaurus CUI : CL525731;
Origin ID : C138164;
UMLS CUI : C4527411;
Semantic type(s)
- concept_is_in_subset
- has_target
