Preferred Label : Patritumab Deruxtecan;
NCIt synonyms : Anti-HER3 Antibody-drug Conjugate U3 1402;
NCIt definition : An antibody-drug conjugate (ADC) composed of patritumab, a monoclonal antibody directed
against the human epidermal growth factor receptor HER3 (ErbB3),linked to the topoisomerase
I inhibitor DX 8951, a semisynthetic, water-soluble derivative of camptothecin, with
potential antineoplastic activity. Upon administration of patritumab deruxtecan, the
patritumab moiety targets and binds to HER3. After internalization, DX 8951 inhibits
topoisomerase I activity by stabilizing the complex between topoisomerase I and DNA
and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering
apoptotic cell death. HER3, a member of the epidermal growth factor receptor (EGFR)
family of receptor tyrosine kinases, is frequently overexpressed in tumors.;
UNII : 3XPI7EG4W8;
CAS number : 2227102-46-5;
Molecule name : U3-1402a; U3 1402; U3-1402;
NCI Metathesaurus CUI : CL524745;
Origin ID : C136987;
UMLS CUI : C5418190;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
