" /> Patritumab Deruxtecan - CISMeF





Preferred Label : Patritumab Deruxtecan;

NCIt synonyms : Anti-HER3 Antibody-drug Conjugate U3 1402;

NCIt definition : An antibody-drug conjugate (ADC) composed of patritumab, a monoclonal antibody directed against the human epidermal growth factor receptor HER3 (ErbB3),linked to the topoisomerase I inhibitor DX 8951, a semisynthetic, water-soluble derivative of camptothecin, with potential antineoplastic activity. Upon administration of patritumab deruxtecan, the patritumab moiety targets and binds to HER3. After internalization, DX 8951 inhibits topoisomerase I activity by stabilizing the complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors.;

UNII : 3XPI7EG4W8;

CAS number : 2227102-46-5;

Molecule name : U3-1402a; U3 1402; U3-1402;

NCI Metathesaurus CUI : CL524745;

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27/07/2025


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