Preferred Label : Anti-CLDN6/9 Antibody-drug Conjugate SC-004;
NCIt synonyms : Anti-CLDN6/9 ADC SC-004;
NCIt related terms : SC-004;
NCIt definition : An antibody-drug conjugate (ADC) composed of a proprietary monoclonal antibody directed
against claudin-6 (CLDN6; CLDN-6) and claudin-9 (CLDN9; CLDN-9) linked to a cytotoxic
pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity. Upon intravenous
administration, the monoclonal antibody moiety of anti-CLDN6/9 ADC SC-004 targets
and binds to CLDN6/9 expressed on tumor cells, and the PBD moiety is released. Then
the imine groups of the PBD moiety bind to the N2 positions of guanines on opposite
strands of DNA. This induces DNA strand breaks, inhibits DNA replication, leads to
G2/M cell cycle arrest, induces cell death, and inhibits the proliferation of CLDN6/9-overexpressing
tumor cells. CLDN6, a transmembrane tight-junction protein and embryonic antigen,
is overexpressed on a variety of tumor cells but is not expressed on normal, healthy
adult cells. CLDN6 and CLDN9 differ at only 3 out of 76 residues in their extracellular
loops, and CLDN9 is highly expressed in some normal tissues in addition to some tumors.;
UNII : EBA1W201ZY;
Molecule name : SC 004; SC-004;
Origin ID : C136807;
UMLS CUI : C0967625;
Currated CISMeF NLP mapping
- SC004 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- SC004 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
