Pyruvate Kinase PKM Isoform M2 Dimer

Preferred Label : Pyruvate Kinase PKM Isoform M2 Dimer;

NCIt synonyms : Tumor M2-PK; M2-PK;

NCIt definition : A homodimer of the pyruvate kinase PKM isoform M2. This enzyme complex promotes cellular metabolism and is overexpressed in tumors.;

NCIt note : M2-PK may be used as a biomarker for colorectal cancer in fecal testing or as a marker for pancreatic, gastric, esophageal, colorectal and cholangiocellular cancer in plasma screening.;

NCI Metathesaurus CUI : CL524466;

Details

Origin ID

C136626;

UMLS CUI

C4526835;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Phosphotransferase [NCIt concept]
gene_product_has_chemical_classification
- Pyruvate Kinase [NCIt concept]

Keyword's position in hierarchy(ies) :

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