Preferred Label : HDM2-binding Peptide PNC-27;
NCIt synonyms : PNC-27 Anti-Cancer Peptide;
NCIt definition : A human double minute 2 (HDM2)-binding peptide comprised of a carboxy terminal p53
leader sequence (amino acids 12-26) linked to a membrane residency peptide (MRP),
which facilitates penetration of the tumor cell plasma membrane, with potential antineoplastic
activity. HDM2-binding peptide PNC-27 binds to HDM2, which is expressed in the plasma
membrane of certain cancer cells, and induces transmembrane pore formation, resulting
in tumor cell necrosis that is independent of p53 activity. HDM2, a zinc finger protein
and negative regulator of the p53 pathway, is often overexpressed by cancer cells
and has been implicated in cancer cell proliferation and survival.;
Molecule name : PNC 27; PNC-27;
Origin ID : C136515;
UMLS CUI : C2934281;
Semantic type(s)
- UMLS correspondences (same concept)
- PNC-27 [MeSH Supplementary Concept]
